Drug interactions
Simvastatin + Vadadustat
Severity: Moderate
Simvastatin and Vadadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat raises simvastatin exposure, increasing the risk of statin-related myopathy.
What this interaction means in plain words
Simvastatin and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Simvastatin belongs to Cardiovascular; Vadadustat belongs to Endocrine.
Why it happens
Vadadustat inhibits BCRP, increasing simvastatin absorption and exposure.
What to do
Start simvastatin at 5 mg daily and do not exceed 20 mg daily during vadadustat therapy. Monitor for muscle symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Simvastatin with Vadadustat?
MediHelp rates the interaction as moderate. Simvastatin and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vadadustat raises simvastatin exposure, increasing the risk of statin-related myopathy.
How serious is the interaction between Simvastatin and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start simvastatin at 5 mg daily and do not exceed 20 mg daily during vadadustat therapy. Monitor for muscle symptoms.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
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