Drug interactions
Siponimod + Talazoparib
Severity: Moderate
Siponimod and Talazoparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Talazoparib commonly causes anaemia, neutropenia and thrombocytopenia. With siponimod's lymphocyte-lowering effect, infection risk may be increased.
What this interaction means in plain words
Siponimod and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Siponimod belongs to Central Nervous System; Talazoparib belongs to Oncology.
Why it happens
Additive effects on blood counts: PARP inhibitor myelosuppression plus S1P receptor-mediated lymphocyte reduction.
What to do
Monitor complete blood counts regularly and follow talazoparib dose-modification guidance for cytopenias. Watch for infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Other interactions of Talazoparib
- Carvedilol + Talazoparib Major
- Itraconazole + Talazoparib Major
- Amiodarone + Talazoparib Moderate
- Azithromycin + Talazoparib Moderate
- Clarithromycin + Talazoparib Moderate
- Cyclosporin + Talazoparib Moderate
Frequently asked questions
Can I take Siponimod with Talazoparib?
MediHelp rates the interaction as moderate. Siponimod and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Talazoparib commonly causes anaemia, neutropenia and thrombocytopenia. With siponimod's lymphocyte-lowering effect, infection risk may be increased.
How serious is the interaction between Siponimod and Talazoparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and follow talazoparib dose-modification guidance for cytopenias. Watch for infection.
What other medicines interact with Siponimod?
MediHelp also lists interactions of Siponimod with, for example, Cladribine, Fingolimod, Fluconazole. The full list is on the Siponimod page.
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