Drug interactions
Sirolimus + Talquetamab
Severity: Moderate
Sirolimus and Talquetamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytokine release syndrome caused by talquetamab temporarily suppresses CYP enzyme activity and may raise sirolimus concentrations. This is most relevant during step-up dosing and for a couple of weeks after the first treatment dose.
What this interaction means in plain words
Sirolimus and Talquetamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sirolimus belongs to Miscellaneous; Talquetamab belongs to Oncology.
Why it happens
Cytokine-mediated downregulation of CYP3A4 reduces sirolimus clearance.
What to do
Monitor sirolimus trough concentrations and signs of toxicity during step-up dosing and any CRS episode. Adjust the sirolimus dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Talquetamab
- Clozapine + Talquetamab Major
- Pimozide + Talquetamab Major
- Bendamustine + Talquetamab Moderate
- Carbamazepine + Talquetamab Moderate
- Clomipramine + Talquetamab Moderate
- Colchicine + Talquetamab Moderate
Frequently asked questions
Can I take Sirolimus with Talquetamab?
MediHelp rates the interaction as moderate. Sirolimus and Talquetamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cytokine release syndrome caused by talquetamab temporarily suppresses CYP enzyme activity and may raise sirolimus concentrations. This is most relevant during step-up dosing and for a couple of weeks after the first treatment dose.
How serious is the interaction between Sirolimus and Talquetamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough concentrations and signs of toxicity during step-up dosing and any CRS episode. Adjust the sirolimus dose as needed.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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