Drug interactions
Sirolimus + Tazemetostat
Severity: Moderate
Sirolimus and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak CYP3A4 inducer and may lower sirolimus exposure, while sirolimus as a weak CYP3A4 inhibitor may raise tazemetostat levels. Net effects are probably modest but could affect efficacy or toxicity of either drug.
What this interaction means in plain words
Sirolimus and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sirolimus belongs to Miscellaneous; Tazemetostat belongs to Miscellaneous.
Why it happens
Bidirectional CYP3A4 effects: weak induction by tazemetostat and weak inhibition by sirolimus.
What to do
Monitor sirolimus trough concentrations and adjust the dose accordingly. Watch for tazemetostat adverse effects and reduce the dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Sirolimus and Tazemetostat, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Sirolimus with Tazemetostat?
MediHelp rates the interaction as moderate. Sirolimus and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is a weak CYP3A4 inducer and may lower sirolimus exposure, while sirolimus as a weak CYP3A4 inhibitor may raise tazemetostat levels. Net effects are probably modest but could affect efficacy or toxicity of either drug.
How serious is the interaction between Sirolimus and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough concentrations and adjust the dose accordingly. Watch for tazemetostat adverse effects and reduce the dose if they occur.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
