Drug interactions
Sirolimus + Teduglutide
Severity: Moderate
Sirolimus and Teduglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teduglutide enhances intestinal fluid absorption and may increase the absorption of oral drugs. Sirolimus has a narrow therapeutic index, so higher exposure is possible.
What this interaction means in plain words
Sirolimus and Teduglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sirolimus belongs to Miscellaneous; Teduglutide belongs to Endocrine.
Why it happens
Improved intestinal absorptive capacity from teduglutide may increase oral sirolimus absorption.
What to do
Monitor sirolimus trough concentrations when starting or stopping teduglutide. Adjust the sirolimus dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Teduglutide
- Chlordiazepoxide + Teduglutide Moderate
- Clonazepam + Teduglutide Moderate
- Colchicine + Teduglutide Moderate
- Cyclosporin + Teduglutide Moderate
- Digoxin + Teduglutide Moderate
- Ethosuximide + Teduglutide Moderate
Frequently asked questions
Can I take Sirolimus with Teduglutide?
MediHelp rates the interaction as moderate. Sirolimus and Teduglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teduglutide enhances intestinal fluid absorption and may increase the absorption of oral drugs. Sirolimus has a narrow therapeutic index, so higher exposure is possible.
How serious is the interaction between Sirolimus and Teduglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough concentrations when starting or stopping teduglutide. Adjust the sirolimus dose as needed.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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