Drug interactions
Sirolimus + Trastuzumab deruxtecan
Severity: Moderate
Sirolimus and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can suppress immune function, and trastuzumab deruxtecan commonly causes neutropenia. Together they may increase the risk of serious infection.
What this interaction means in plain words
Sirolimus and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sirolimus belongs to Miscellaneous; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive immunosuppression and myelosuppression.
What to do
Monitor blood counts and watch closely for infection. Consider whether the sirolimus dose should be reduced during neutropenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Sirolimus with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Sirolimus and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can suppress immune function, and trastuzumab deruxtecan commonly causes neutropenia. Together they may increase the risk of serious infection.
How serious is the interaction between Sirolimus and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and watch closely for infection. Consider whether the sirolimus dose should be reduced during neutropenia.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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