Drug interactions
Sirolimus + Trofinetide
Severity: Moderate
Sirolimus and Trofinetide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trofinetide is a weak CYP3A4 inhibitor and may raise sirolimus concentrations. Because sirolimus has a narrow therapeutic range, even a small rise can matter.
What this interaction means in plain words
Sirolimus and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sirolimus belongs to Miscellaneous; Trofinetide belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by trofinetide reduces sirolimus metabolism.
What to do
Monitor sirolimus trough levels and adverse effects after trofinetide is started or stopped. Adjust the dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Trofinetide
Frequently asked questions
Can I take Sirolimus with Trofinetide?
MediHelp rates the interaction as moderate. Sirolimus and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trofinetide is a weak CYP3A4 inhibitor and may raise sirolimus concentrations. Because sirolimus has a narrow therapeutic range, even a small rise can matter.
How serious is the interaction between Sirolimus and Trofinetide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough levels and adverse effects after trofinetide is started or stopped. Adjust the dose accordingly.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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