Drug interactions
Sirolimus + Vemurafenib
Severity: Moderate
Sirolimus and Vemurafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib inhibits P-glycoprotein and may increase sirolimus exposure. It also has variable effects on CYP3A4, so the net change is unpredictable.
What this interaction means in plain words
Sirolimus and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sirolimus belongs to Miscellaneous; Vemurafenib belongs to Oncology.
Why it happens
Vemurafenib inhibits P-glycoprotein efflux of sirolimus, with variable CYP3A4 effects.
What to do
Monitor sirolimus trough levels when starting or stopping vemurafenib. Adjust the sirolimus dose to maintain the target range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Vemurafenib
Frequently asked questions
Can I take Sirolimus with Vemurafenib?
MediHelp rates the interaction as moderate. Sirolimus and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vemurafenib inhibits P-glycoprotein and may increase sirolimus exposure. It also has variable effects on CYP3A4, so the net change is unpredictable.
How serious is the interaction between Sirolimus and Vemurafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough levels when starting or stopping vemurafenib. Adjust the sirolimus dose to maintain the target range.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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