Drug interactions
Sitagliptin + Stiripentol
Severity: Minor
Sitagliptin and Stiripentol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits P-glycoprotein and may increase sitagliptin exposure. Clinical consequences are expected to be small given the wide safety margin of sitagliptin.
What this interaction means in plain words
Sitagliptin and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sitagliptin belongs to Endocrine; Stiripentol belongs to Central Nervous System.
Why it happens
Inhibition of P-glycoprotein efflux by stiripentol may raise sitagliptin concentrations.
What to do
No routine dose change is needed. Monitor for sitagliptin adverse effects and reduce the dose only if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sitagliptin
- Albiglutide + Sitagliptin Moderate
- Amlodipine-benazepril + Sitagliptin Moderate
- Aripiprazole + Sitagliptin Moderate
- Asenapine + Sitagliptin Moderate
- Benazepril + Sitagliptin Moderate
- Captopril-hydrochlorothiazide + Sitagliptin Moderate
Other interactions of Stiripentol
Frequently asked questions
Can I take Sitagliptin with Stiripentol?
MediHelp rates the interaction as minor. Sitagliptin and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stiripentol inhibits P-glycoprotein and may increase sitagliptin exposure. Clinical consequences are expected to be small given the wide safety margin of sitagliptin.
How serious is the interaction between Sitagliptin and Stiripentol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for sitagliptin adverse effects and reduce the dose only if they occur.
What other medicines interact with Sitagliptin?
MediHelp also lists interactions of Sitagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Sitagliptin page.
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