Drug interactions
Sitagliptin + Vadadustat
Severity: Minor
Sitagliptin and Vadadustat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat inhibits OAT3, a transporter involved in renal secretion of sitagliptin, and could raise sitagliptin levels. The effect is expected to be modest.
What this interaction means in plain words
Sitagliptin and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sitagliptin belongs to Endocrine; Vadadustat belongs to Endocrine.
Why it happens
Inhibition of renal OAT3 transport by vadadustat reducing sitagliptin secretion.
What to do
Monitor for sitagliptin adverse effects and renal function. Dose adjustment is usually unnecessary.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sitagliptin
- Albiglutide + Sitagliptin Moderate
- Amlodipine-benazepril + Sitagliptin Moderate
- Aripiprazole + Sitagliptin Moderate
- Asenapine + Sitagliptin Moderate
- Benazepril + Sitagliptin Moderate
- Captopril-hydrochlorothiazide + Sitagliptin Moderate
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Sitagliptin with Vadadustat?
MediHelp rates the interaction as minor. Sitagliptin and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vadadustat inhibits OAT3, a transporter involved in renal secretion of sitagliptin, and could raise sitagliptin levels. The effect is expected to be modest.
How serious is the interaction between Sitagliptin and Vadadustat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sitagliptin adverse effects and renal function. Dose adjustment is usually unnecessary.
What other medicines interact with Sitagliptin?
MediHelp also lists interactions of Sitagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Sitagliptin page.
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