Drug interactions
Sofosbuvir-velpatasvir + Tepotinib
Severity: Moderate
Sofosbuvir-velpatasvir and Tepotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits intestinal P-glycoprotein, and both sofosbuvir and velpatasvir are P-gp substrates. Coadministration may raise their plasma concentrations. The clinical consequence is probably modest given the wide safety margin of the HCV combination.
What this interaction means in plain words
Sofosbuvir-velpatasvir and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sofosbuvir-velpatasvir belongs to Anti Virals; Tepotinib belongs to Oncology.
Why it happens
Tepotinib inhibits P-gp efflux, which can increase absorption and exposure of sofosbuvir and velpatasvir.
What to do
Monitor for adverse effects of the HCV regimen such as headache, fatigue and nausea during coadministration. Consider an alternative only if tolerability problems arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir
- Rifampin + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Sofosbuvir-velpatasvir + St john's wort Contraindicated
- Amiodarone + Sofosbuvir-velpatasvir Major
- Apalutamide + Sofosbuvir-velpatasvir Major
- Carbamazepine + Sofosbuvir-velpatasvir Major
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
Frequently asked questions
Can I take Sofosbuvir-velpatasvir with Tepotinib?
MediHelp rates the interaction as moderate. Sofosbuvir-velpatasvir and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tepotinib inhibits intestinal P-glycoprotein, and both sofosbuvir and velpatasvir are P-gp substrates. Coadministration may raise their plasma concentrations. The clinical consequence is probably modest given the wide safety margin of the HCV combination.
How serious is the interaction between Sofosbuvir-velpatasvir and Tepotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects of the HCV regimen such as headache, fatigue and nausea during coadministration. Consider an alternative only if tolerability problems arise.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
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