Drug interactions
Sofosbuvir-velpatasvir-voxilaprevir + Tazemetostat
Severity: Moderate
Sofosbuvir-velpatasvir-voxilaprevir and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak-to-moderate CYP3A4 inducer and may reduce velpatasvir and voxilaprevir concentrations. Lower antiviral exposure could reduce the likelihood of HCV cure.
What this interaction means in plain words
Sofosbuvir-velpatasvir-voxilaprevir and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals; Tazemetostat belongs to Miscellaneous.
Why it happens
Induction of CYP3A4 by tazemetostat increases metabolism of velpatasvir and voxilaprevir.
What to do
Monitor HCV RNA response and confirm a sustained virologic response. Consider alternatives to tazemetostat or specialist input if viral load does not fall as expected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Sofosbuvir-velpatasvir-voxilaprevir with Tazemetostat?
MediHelp rates the interaction as moderate. Sofosbuvir-velpatasvir-voxilaprevir and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is a weak-to-moderate CYP3A4 inducer and may reduce velpatasvir and voxilaprevir concentrations. Lower antiviral exposure could reduce the likelihood of HCV cure.
How serious is the interaction between Sofosbuvir-velpatasvir-voxilaprevir and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HCV RNA response and confirm a sustained virologic response. Consider alternatives to tazemetostat or specialist input if viral load does not fall as expected.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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