Drug interactions
Sofosbuvir-velpatasvir-voxilaprevir + Tecovirimat
Severity: Minor
Sofosbuvir-velpatasvir-voxilaprevir and Tecovirimat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tecovirimat weakly inhibits CYP2C8 and CYP2C19 and may weakly induce CYP3A4. Changes in velpatasvir and voxilaprevir exposure are expected to be small and clinically modest.
What this interaction means in plain words
Sofosbuvir-velpatasvir-voxilaprevir and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals; Tecovirimat belongs to Miscellaneous.
Why it happens
Weak inhibition of CYP2C8/CYP2C19 and weak CYP3A4 induction by tecovirimat may slightly alter velpatasvir and voxilaprevir metabolism.
What to do
No dose adjustment is usually needed. Monitor for adverse effects of the antiviral regimen during the short tecovirimat course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Tecovirimat
- Bosentan + Tecovirimat Moderate
- Cyclosporin + Tecovirimat Moderate
- Darunavir + Tecovirimat Moderate
- Ethinyl estradiol-drospirenone + Tecovirimat Moderate
- Ethinyl estradiol-levonorgestrel + Tecovirimat Moderate
- Glimepiride-pioglitazone + Tecovirimat Moderate
Frequently asked questions
Can I take Sofosbuvir-velpatasvir-voxilaprevir with Tecovirimat?
MediHelp rates the interaction as minor. Sofosbuvir-velpatasvir-voxilaprevir and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tecovirimat weakly inhibits CYP2C8 and CYP2C19 and may weakly induce CYP3A4. Changes in velpatasvir and voxilaprevir exposure are expected to be small and clinically modest.
How serious is the interaction between Sofosbuvir-velpatasvir-voxilaprevir and Tecovirimat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Monitor for adverse effects of the antiviral regimen during the short tecovirimat course.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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