Drug interactions
Sofosbuvir-velpatasvir-voxilaprevir + Tipranavir
Severity: Major
Sofosbuvir-velpatasvir-voxilaprevir and Tipranavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir (given with ritonavir) induces P-glycoprotein and can reduce sofosbuvir exposure, and its effect on velpatasvir and voxilaprevir is unpredictable. This may lead to reduced antiviral efficacy.
What this interaction means in plain words
Sofosbuvir-velpatasvir-voxilaprevir and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals; Tipranavir belongs to Anti Virals.
Why it happens
Tipranavir/ritonavir induces P-glycoprotein and has mixed CYP3A4 effects, altering HCV drug absorption and metabolism.
What to do
Labeling advises against coadministration with tipranavir/ritonavir. Use an alternative HIV regimen or HCV regimen.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Sofosbuvir-velpatasvir-voxilaprevir with Tipranavir?
MediHelp rates the interaction as major. Sofosbuvir-velpatasvir-voxilaprevir and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tipranavir (given with ritonavir) induces P-glycoprotein and can reduce sofosbuvir exposure, and its effect on velpatasvir and voxilaprevir is unpredictable. This may lead to reduced antiviral efficacy.
How serious is the interaction between Sofosbuvir-velpatasvir-voxilaprevir and Tipranavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Labeling advises against coadministration with tipranavir/ritonavir. Use an alternative HIV regimen or HCV regimen.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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