Drug interactions
Sofosbuvir-velpatasvir-voxilaprevir + Trofinetide
Severity: Moderate
Sofosbuvir-velpatasvir-voxilaprevir and Trofinetide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trofinetide may inhibit OATP1B1 and OATP1B3, which transport voxilaprevir. Higher voxilaprevir levels could increase adverse effects, although the clinical impact is uncertain.
What this interaction means in plain words
Sofosbuvir-velpatasvir-voxilaprevir and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals; Trofinetide belongs to Central Nervous System.
Why it happens
Inhibition of hepatic OATP1B1/1B3 uptake by trofinetide may raise voxilaprevir plasma concentrations.
What to do
Monitor for gastrointestinal effects and liver tests if coadministered. Consider timing HCV therapy when trofinetide can be paused if clinically appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Trofinetide
Frequently asked questions
Can I take Sofosbuvir-velpatasvir-voxilaprevir with Trofinetide?
MediHelp rates the interaction as moderate. Sofosbuvir-velpatasvir-voxilaprevir and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trofinetide may inhibit OATP1B1 and OATP1B3, which transport voxilaprevir. Higher voxilaprevir levels could increase adverse effects, although the clinical impact is uncertain.
How serious is the interaction between Sofosbuvir-velpatasvir-voxilaprevir and Trofinetide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal effects and liver tests if coadministered. Consider timing HCV therapy when trofinetide can be paused if clinically appropriate.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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