Drug interactions
Sofosbuvir-velpatasvir-voxilaprevir + Voriconazole
Severity: Minor
Sofosbuvir-velpatasvir-voxilaprevir and Voriconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP3A4 and may modestly increase velpatasvir and voxilaprevir exposure. Because multiple pathways are involved, a clinically important effect is unlikely.
What this interaction means in plain words
Sofosbuvir-velpatasvir-voxilaprevir and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4, one of several enzymes metabolizing velpatasvir and voxilaprevir.
What to do
No dose adjustment is needed; monitor for adverse effects such as headache, nausea and diarrhea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Sofosbuvir-velpatasvir-voxilaprevir with Voriconazole?
MediHelp rates the interaction as minor. Sofosbuvir-velpatasvir-voxilaprevir and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voriconazole inhibits CYP3A4 and may modestly increase velpatasvir and voxilaprevir exposure. Because multiple pathways are involved, a clinically important effect is unlikely.
How serious is the interaction between Sofosbuvir-velpatasvir-voxilaprevir and Voriconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for adverse effects such as headache, nausea and diarrhea.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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