Drug interactions
Solifenacin + Tacrolimus
Severity: Moderate
Solifenacin and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus can prolong the QT interval and solifenacin may add to the effect. Tacrolimus is a CYP3A4 substrate with weak inhibitory effects, so exposure to solifenacin could rise slightly.
What this interaction means in plain words
Solifenacin and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Solifenacin belongs to Genitourinary; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive QT prolongation, with possible minor CYP3A4 competition.
What to do
Monitor the ECG and electrolytes, particularly in transplant patients with magnesium or potassium disturbances. Watch for anticholinergic effects if solifenacin exposure rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Solifenacin with Tacrolimus?
MediHelp rates the interaction as moderate. Solifenacin and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus can prolong the QT interval and solifenacin may add to the effect. Tacrolimus is a CYP3A4 substrate with weak inhibitory effects, so exposure to solifenacin could rise slightly.
How serious is the interaction between Solifenacin and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG and electrolytes, particularly in transplant patients with magnesium or potassium disturbances. Watch for anticholinergic effects if solifenacin exposure rises.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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