Drug interactions
Solifenacin + Tazemetostat
Severity: Moderate
Solifenacin and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak to moderate CYP3A4 inducer and may reduce solifenacin concentrations, possibly weakening its effect.
What this interaction means in plain words
Solifenacin and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Solifenacin belongs to Genitourinary; Tazemetostat belongs to Miscellaneous.
Why it happens
Induction of CYP3A4 increases solifenacin metabolism.
What to do
Monitor for reduced symptom control and adjust solifenacin dose to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Tazemetostat
Frequently asked questions
Can I take Solifenacin with Tazemetostat?
MediHelp rates the interaction as moderate. Solifenacin and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is a weak to moderate CYP3A4 inducer and may reduce solifenacin concentrations, possibly weakening its effect.
How serious is the interaction between Solifenacin and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced symptom control and adjust solifenacin dose to response.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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