Drug interactions
Solifenacin + Vemurafenib
Severity: Moderate
Solifenacin and Vemurafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib can prolong the QT interval in a concentration-dependent way, and solifenacin has a modest QT effect at higher doses. Together the risk of serious ventricular arrhythmia may rise.
What this interaction means in plain words
Solifenacin and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Solifenacin belongs to Genitourinary; Vemurafenib belongs to Oncology.
Why it happens
Additive QT interval prolongation; vemurafenib also weakly induces CYP3A4, which may lower solifenacin exposure.
What to do
Obtain ECG and electrolytes at baseline and during treatment, and correct hypokalemia or hypomagnesemia. Choose an alternative bladder agent if QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Solifenacin and Vemurafenib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Solifenacin
Other interactions of Vemurafenib
Frequently asked questions
Can I take Solifenacin with Vemurafenib?
MediHelp rates the interaction as moderate. Solifenacin and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vemurafenib can prolong the QT interval in a concentration-dependent way, and solifenacin has a modest QT effect at higher doses. Together the risk of serious ventricular arrhythmia may rise.
How serious is the interaction between Solifenacin and Vemurafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain ECG and electrolytes at baseline and during treatment, and correct hypokalemia or hypomagnesemia. Choose an alternative bladder agent if QTc becomes prolonged.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
