Drug interactions
Solifenacin + Voriconazole
Severity: Major
Solifenacin and Voriconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole prolongs the QT interval and also inhibits CYP3A4, which metabolizes solifenacin, raising solifenacin exposure. Together these effects increase the risk of QT prolongation and arrhythmia.
What this interaction means in plain words
Solifenacin and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Solifenacin belongs to Genitourinary; Voriconazole belongs to Anti Fungals.
Why it happens
Additive QT prolongation plus CYP3A4 inhibition by voriconazole reducing solifenacin clearance.
What to do
Limit solifenacin to 5 mg daily during voriconazole therapy, and obtain an ECG and check electrolytes in at-risk patients. Consider an alternative antimuscarinic or antifungal if the QTc rises.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Solifenacin
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Solifenacin with Voriconazole?
MediHelp rates the interaction as major. Solifenacin and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voriconazole prolongs the QT interval and also inhibits CYP3A4, which metabolizes solifenacin, raising solifenacin exposure. Together these effects increase the risk of QT prolongation and arrhythmia.
How serious is the interaction between Solifenacin and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit solifenacin to 5 mg daily during voriconazole therapy, and obtain an ECG and check electrolytes in at-risk patients. Consider an alternative antimuscarinic or antifungal if the QTc rises.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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