Drug interactions
Solifenacin + Vorinostat
Severity: Moderate
Solifenacin and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorinostat has been associated with QT prolongation, and solifenacin has dose-related QT effects. Using both may increase the risk of arrhythmia, especially with electrolyte disturbances.
What this interaction means in plain words
Solifenacin and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Solifenacin belongs to Genitourinary; Vorinostat belongs to Oncology.
Why it happens
Additive QT interval prolongation.
What to do
Monitor ECG and correct potassium and magnesium before and during therapy. Consider an alternative to solifenacin in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Solifenacin with Vorinostat?
MediHelp rates the interaction as moderate. Solifenacin and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vorinostat has been associated with QT prolongation, and solifenacin has dose-related QT effects. Using both may increase the risk of arrhythmia, especially with electrolyte disturbances.
How serious is the interaction between Solifenacin and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and correct potassium and magnesium before and during therapy. Consider an alternative to solifenacin in high-risk patients.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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