Drug interactions
Sonidegib + Voriconazole
Severity: Major
Sonidegib and Voriconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sonidegib is cleared mainly by CYP3A4, and voriconazole inhibits this pathway strongly. Higher sonidegib levels may increase the risk of musculoskeletal toxicity, including rhabdomyolysis and CK elevation.
What this interaction means in plain words
Sonidegib and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Sonidegib belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4-mediated metabolism of sonidegib, increasing its plasma concentrations.
What to do
Avoid the combination where possible. If a strong CYP3A4 inhibitor is needed short term, monitor CK levels and muscle symptoms closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Sonidegib
- Amiodarone + Sonidegib Major
- Apalutamide + Sonidegib Major
- Aprepitant + Sonidegib Major
- Armodafinil + Sonidegib Major
- Bosentan + Sonidegib Major
- Carbamazepine + Sonidegib Major
Frequently asked questions
Can I take Sonidegib with Voriconazole?
MediHelp rates the interaction as major. Sonidegib and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sonidegib is cleared mainly by CYP3A4, and voriconazole inhibits this pathway strongly. Higher sonidegib levels may increase the risk of musculoskeletal toxicity, including rhabdomyolysis and CK elevation.
How serious is the interaction between Sonidegib and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If a strong CYP3A4 inhibitor is needed short term, monitor CK levels and muscle symptoms closely.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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