Drug interactions
Sorafenib + Tucatinib
Severity: Moderate
Sorafenib and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is a strong CYP3A inhibitor and may raise sorafenib exposure, though sorafenib is only partly cleared by CYP3A4 and the effect of inhibitors is modest. Increased adverse effects such as hand-foot reaction, hypertension and diarrhea are possible.
What this interaction means in plain words
Sorafenib and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sorafenib belongs to Oncology; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4, reducing sorafenib oxidative metabolism.
What to do
Monitor for sorafenib toxicity and reduce the dose or interrupt treatment if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sorafenib
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Sorafenib with Tucatinib?
MediHelp rates the interaction as moderate. Sorafenib and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib is a strong CYP3A inhibitor and may raise sorafenib exposure, though sorafenib is only partly cleared by CYP3A4 and the effect of inhibitors is modest. Increased adverse effects such as hand-foot reaction, hypertension and diarrhea are possible.
How serious is the interaction between Sorafenib and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sorafenib toxicity and reduce the dose or interrupt treatment if adverse effects emerge.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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