Drug interactions
Sotalol + Tolfenamic acid
Severity: Moderate
Sotalol and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the antihypertensive effect of beta-blockers, particularly with sustained use. NSAIDs may also impair renal function and cause fluid retention, which can affect sotalol clearance and raise the risk of toxicity such as QT prolongation in renal impairment.
What this interaction means in plain words
Sotalol and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sotalol belongs to Cardiovascular; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of prostaglandin synthesis causes sodium and water retention and reduces vasodilation, opposing the beta-blocker's blood pressure effect.
What to do
Monitor blood pressure and renal function if NSAID use extends beyond a few days. Use the lowest effective NSAID dose for the shortest time, or consider paracetamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Sotalol and Tolfenamic acid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Sotalol with Tolfenamic acid?
MediHelp rates the interaction as moderate. Sotalol and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the antihypertensive effect of beta-blockers, particularly with sustained use. NSAIDs may also impair renal function and cause fluid retention, which can affect sotalol clearance and raise the risk of toxicity such as QT prolongation in renal impairment.
How serious is the interaction between Sotalol and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function if NSAID use extends beyond a few days. Use the lowest effective NSAID dose for the shortest time, or consider paracetamol.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
