Drug interactions
Sparsentan + Trimipramine
Severity: Moderate
Sparsentan and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan may induce CYP2C19, which contributes to trimipramine metabolism. Trimipramine exposure may be lowered, possibly reducing antidepressant effect.
What this interaction means in plain words
Sparsentan and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sparsentan belongs to Genitourinary; Trimipramine belongs to Central Nervous System.
Why it happens
CYP2C19 induction by sparsentan increases trimipramine clearance.
What to do
Monitor clinical response to trimipramine and consider plasma level monitoring. Adjust the dose if response is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Sparsentan with Trimipramine?
MediHelp rates the interaction as moderate. Sparsentan and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sparsentan may induce CYP2C19, which contributes to trimipramine metabolism. Trimipramine exposure may be lowered, possibly reducing antidepressant effect.
How serious is the interaction between Sparsentan and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to trimipramine and consider plasma level monitoring. Adjust the dose if response is lost.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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