Drug interactions
Stiripentol + Terbinafine
Severity: Minor
Stiripentol and Terbinafine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol has both inhibitory and inductive effects on CYP1A2 and CYP3A4, so terbinafine levels may go up or down unpredictably. The clinical effect has not been well characterized.
What this interaction means in plain words
Stiripentol and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Stiripentol belongs to Central Nervous System; Terbinafine belongs to Anti Fungals.
Why it happens
Stiripentol inhibits and induces CYP1A2 and CYP3A4, which contribute to terbinafine metabolism; the net effect is uncertain.
What to do
Monitor antifungal response and terbinafine tolerability, including liver function if symptoms occur, and adjust therapy based on outcome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Stiripentol with Terbinafine?
MediHelp rates the interaction as minor. Stiripentol and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stiripentol has both inhibitory and inductive effects on CYP1A2 and CYP3A4, so terbinafine levels may go up or down unpredictably. The clinical effect has not been well characterized.
How serious is the interaction between Stiripentol and Terbinafine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor antifungal response and terbinafine tolerability, including liver function if symptoms occur, and adjust therapy based on outcome.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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