Drug interactions
Stiripentol + Thioridazine
Severity: Major
Stiripentol and Thioridazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, so combined use may increase somnolence and impair alertness. Stiripentol also inhibits several CYP enzymes, including CYP2D6, which could raise thioridazine levels and its cardiac risk.
What this interaction means in plain words
Stiripentol and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Stiripentol belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
Why it happens
Additive CNS depression plus possible stiripentol inhibition of CYP2D6 and CYP1A2, reducing thioridazine metabolism.
What to do
Monitor sedation and ECG/QTc, and consider a lower thioridazine dose or an alternative antipsychotic. Counsel patients about driving and machinery.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Stiripentol and Thioridazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Stiripentol with Thioridazine?
MediHelp rates the interaction as major. Stiripentol and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs cause sedation, so combined use may increase somnolence and impair alertness. Stiripentol also inhibits several CYP enzymes, including CYP2D6, which could raise thioridazine levels and its cardiac risk.
How serious is the interaction between Stiripentol and Thioridazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and ECG/QTc, and consider a lower thioridazine dose or an alternative antipsychotic. Counsel patients about driving and machinery.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
