Drug interactions
Stiripentol + Ticagrelor
Severity: Moderate
Stiripentol and Ticagrelor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol can both inhibit and induce CYP3A4. Ticagrelor is a CYP3A4 substrate, so exposure may rise or fall, causing bleeding or loss of antiplatelet effect.
What this interaction means in plain words
Stiripentol and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Stiripentol belongs to Central Nervous System; Ticagrelor belongs to Cardiovascular.
Why it happens
Stiripentol alters CYP3A4 activity, unpredictably changing ticagrelor clearance.
What to do
Monitor for bleeding and ischemic events, and consider an alternative antiplatelet if the effect is unclear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Stiripentol with Ticagrelor?
MediHelp rates the interaction as moderate. Stiripentol and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol can both inhibit and induce CYP3A4. Ticagrelor is a CYP3A4 substrate, so exposure may rise or fall, causing bleeding or loss of antiplatelet effect.
How serious is the interaction between Stiripentol and Ticagrelor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and ischemic events, and consider an alternative antiplatelet if the effect is unclear.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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