Drug interactions
Stiripentol + Tinidazole
Severity: Minor
Stiripentol and Tinidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits and induces several CYP enzymes including CYP3A4, so it could alter tinidazole exposure in either direction. The net effect is unpredictable and probably modest because tinidazole also has renal elimination, and no clinical data are available.
What this interaction means in plain words
Stiripentol and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Stiripentol belongs to Central Nervous System; Tinidazole belongs to Anti Parasitic.
Why it happens
Mixed CYP3A4 inhibition and induction by stiripentol may alter tinidazole metabolism.
What to do
No empirical dose change is needed; monitor for tinidazole adverse effects or reduced efficacy during a short course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Stiripentol with Tinidazole?
MediHelp rates the interaction as minor. Stiripentol and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stiripentol inhibits and induces several CYP enzymes including CYP3A4, so it could alter tinidazole exposure in either direction. The net effect is unpredictable and probably modest because tinidazole also has renal elimination, and no clinical data are available.
How serious is the interaction between Stiripentol and Tinidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor for tinidazole adverse effects or reduced efficacy during a short course.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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