Drug interactions
Stiripentol + Topotecan
Severity: Moderate
Stiripentol and Topotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits P-glycoprotein and BCRP, transporters that handle topotecan. This may increase topotecan exposure and the risk of myelosuppression and gastrointestinal toxicity.
What this interaction means in plain words
Stiripentol and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Stiripentol belongs to Central Nervous System; Topotecan belongs to Oncology.
Why it happens
Stiripentol inhibits P-gp and BCRP, reducing topotecan efflux.
What to do
Monitor complete blood counts closely and reduce the topotecan dose if adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporine + Topotecan Major
- Cyclosporin + Topotecan Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Stiripentol with Topotecan?
MediHelp rates the interaction as moderate. Stiripentol and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits P-glycoprotein and BCRP, transporters that handle topotecan. This may increase topotecan exposure and the risk of myelosuppression and gastrointestinal toxicity.
How serious is the interaction between Stiripentol and Topotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely and reduce the topotecan dose if adverse effects develop.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Adenovirus types 4 and 7 live, Amiodarone, Cisplatin. The full list is on the Topotecan page.
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