Drug interactions
Stiripentol + Umeclidinium-vilanterol
Severity: Minor
Stiripentol and Umeclidinium-vilanterol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol both inhibits and induces CYP3A4, so vilanterol exposure may rise or fall unpredictably. The effect is probably small with inhaled dosing.
What this interaction means in plain words
Stiripentol and Umeclidinium-vilanterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Stiripentol belongs to Central Nervous System; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Stiripentol variably inhibits and induces CYP3A4, altering vilanterol metabolism.
What to do
Monitor for reduced bronchodilator response or beta-agonist adverse effects when stiripentol is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Stiripentol
Frequently asked questions
Can I take Stiripentol with Umeclidinium-vilanterol?
MediHelp rates the interaction as minor. Stiripentol and Umeclidinium-vilanterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stiripentol both inhibits and induces CYP3A4, so vilanterol exposure may rise or fall unpredictably. The effect is probably small with inhaled dosing.
How serious is the interaction between Stiripentol and Umeclidinium-vilanterol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced bronchodilator response or beta-agonist adverse effects when stiripentol is started or stopped.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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