Drug interactions
Stiripentol + Vardenafil
Severity: Moderate
Stiripentol and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits and may also induce CYP3A4, so vardenafil exposure may change unpredictably. This may lead to either increased adverse effects or reduced efficacy.
What this interaction means in plain words
Stiripentol and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Stiripentol belongs to Central Nervous System; Vardenafil belongs to Genitourinary.
Why it happens
Mixed CYP3A4 inhibition and induction by stiripentol alters vardenafil metabolism.
What to do
Start with a low vardenafil dose and titrate according to response and tolerability, monitoring blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Stiripentol with Vardenafil?
MediHelp rates the interaction as moderate. Stiripentol and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits and may also induce CYP3A4, so vardenafil exposure may change unpredictably. This may lead to either increased adverse effects or reduced efficacy.
How serious is the interaction between Stiripentol and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a low vardenafil dose and titrate according to response and tolerability, monitoring blood pressure.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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