Drug interactions
Stiripentol + Verapamil
Severity: Moderate
Stiripentol and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits and induces CYP3A4 and inhibits P-glycoprotein, so verapamil exposure may rise or fall unpredictably. This could lead to hypotension, bradycardia or loss of efficacy.
What this interaction means in plain words
Stiripentol and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Stiripentol belongs to Central Nervous System; Verapamil belongs to Cardiovascular.
Why it happens
Mixed CYP3A4 inhibition and induction plus P-glycoprotein inhibition by stiripentol alter verapamil disposition.
What to do
Monitor heart rate, blood pressure and ECG and titrate verapamil to response. Reduce the dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Stiripentol and Verapamil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Stiripentol with Verapamil?
MediHelp rates the interaction as moderate. Stiripentol and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits and induces CYP3A4 and inhibits P-glycoprotein, so verapamil exposure may rise or fall unpredictably. This could lead to hypotension, bradycardia or loss of efficacy.
How serious is the interaction between Stiripentol and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG and titrate verapamil to response. Reduce the dose if adverse effects occur.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
