Drug interactions
Stiripentol + Vinblastine
Severity: Moderate
Stiripentol and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits CYP3A4 and P-glycoprotein and can also induce CYP3A4, so its effect on vinblastine exposure is unpredictable. Increased exposure would raise the risk of myelosuppression and neurotoxicity.
What this interaction means in plain words
Stiripentol and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Stiripentol belongs to Central Nervous System; Vinblastine belongs to Oncology.
Why it happens
Mixed CYP3A4 inhibition and induction plus P-glycoprotein inhibition by stiripentol alter vinblastine clearance.
What to do
Monitor blood counts and neurotoxicity, and adjust vinblastine dose based on toxicity and response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinblastine
Other interactions of Stiripentol
Frequently asked questions
Can I take Stiripentol with Vinblastine?
MediHelp rates the interaction as moderate. Stiripentol and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits CYP3A4 and P-glycoprotein and can also induce CYP3A4, so its effect on vinblastine exposure is unpredictable. Increased exposure would raise the risk of myelosuppression and neurotoxicity.
How serious is the interaction between Stiripentol and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neurotoxicity, and adjust vinblastine dose based on toxicity and response.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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