Drug interactions
Stiripentol + Ziprasidone
Severity: Moderate
Stiripentol and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol commonly causes somnolence, and ziprasidone is also sedating, so the two together can increase drowsiness and impaired alertness. Stiripentol inhibits several CYP enzymes, which may also modestly raise ziprasidone exposure.
What this interaction means in plain words
Stiripentol and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Stiripentol belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive CNS depression, with possible CYP3A4 inhibition by stiripentol raising ziprasidone levels.
What to do
Monitor for excessive sedation and reduce the dose of either drug if needed. Consider ECG monitoring if other QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Stiripentol with Ziprasidone?
MediHelp rates the interaction as moderate. Stiripentol and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol commonly causes somnolence, and ziprasidone is also sedating, so the two together can increase drowsiness and impaired alertness. Stiripentol inhibits several CYP enzymes, which may also modestly raise ziprasidone exposure.
How serious is the interaction between Stiripentol and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and reduce the dose of either drug if needed. Consider ECG monitoring if other QT risk factors are present.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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