Drug interactions
Sufentanil + Trazodone
Severity: Major
Sufentanil and Trazodone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids and trazodone both cause sedation, so combining them can deepen CNS and respiratory depression. Trazodone also has serotonergic activity, which adds a small risk of serotonin syndrome with some opioids.
What this interaction means in plain words
Sufentanil and Trazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Sufentanil belongs to Musculoskeletal; Trazodone belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depression, with a possible minor serotonergic contribution.
What to do
Use reduced doses and monitor sedation, respiratory rate and oxygen saturation, especially after dose changes. Watch for agitation, tremor or hyperthermia suggesting serotonin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Sufentanil with Trazodone?
MediHelp rates the interaction as major. Sufentanil and Trazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids and trazodone both cause sedation, so combining them can deepen CNS and respiratory depression. Trazodone also has serotonergic activity, which adds a small risk of serotonin syndrome with some opioids.
How serious is the interaction between Sufentanil and Trazodone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use reduced doses and monitor sedation, respiratory rate and oxygen saturation, especially after dose changes. Watch for agitation, tremor or hyperthermia suggesting serotonin toxicity.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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