Drug interactions
Sulindac + Travoprost
Severity: Minor
Sulindac and Travoprost: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ophthalmic prostaglandin analogues act partly through prostaglandin pathways, and NSAIDs may modify their effect on intraocular pressure. Reports are conflicting, and systemic exposure to travoprost is minimal, so any effect is likely small.
What this interaction means in plain words
Sulindac and Travoprost have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sulindac belongs to Musculoskeletal; Travoprost belongs to Miscellaneous.
Why it happens
NSAID cyclooxygenase inhibition may alter endogenous prostaglandin signaling relevant to aqueous humor outflow, but the mechanism is not established.
What to do
No routine change is needed; check intraocular pressure at routine follow-up if systemic NSAIDs are used long term in a glaucoma patient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Travoprost
- Bimatoprost + Travoprost Moderate
- Latanoprostene bunod + Travoprost Moderate
- Latanoprost + Travoprost Moderate
- Tafluprost + Travoprost Moderate
- Celecoxib + Travoprost Minor
- Diclofenac + Travoprost Minor
Frequently asked questions
Can I take Sulindac with Travoprost?
MediHelp rates the interaction as minor. Sulindac and Travoprost have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ophthalmic prostaglandin analogues act partly through prostaglandin pathways, and NSAIDs may modify their effect on intraocular pressure. Reports are conflicting, and systemic exposure to travoprost is minimal, so any effect is likely small.
How serious is the interaction between Sulindac and Travoprost?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; check intraocular pressure at routine follow-up if systemic NSAIDs are used long term in a glaucoma patient.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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