Drug interactions
Sulindac + Trazodone
Severity: Moderate
Sulindac and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone has serotonergic activity and can impair platelet function, and combined with an NSAID it raises the risk of gastrointestinal and other bleeding. The risk is greater in older patients and those with prior ulcers.
What this interaction means in plain words
Sulindac and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sulindac belongs to Musculoskeletal; Trazodone belongs to Central Nervous System.
Why it happens
Serotonin reuptake inhibition depletes platelet serotonin and impairs aggregation, adding to NSAID platelet inhibition and mucosal injury.
What to do
Monitor for signs of bleeding and consider a proton pump inhibitor in high-risk patients. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Sulindac with Trazodone?
MediHelp rates the interaction as moderate. Sulindac and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone has serotonergic activity and can impair platelet function, and combined with an NSAID it raises the risk of gastrointestinal and other bleeding. The risk is greater in older patients and those with prior ulcers.
How serious is the interaction between Sulindac and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and consider a proton pump inhibitor in high-risk patients. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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