Drug interactions
Sulindac + Vortioxetine
Severity: Moderate
Sulindac and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vortioxetine inhibits serotonin reuptake and can impair platelet function, so combined with an NSAID it increases the risk of bleeding, notably in the gastrointestinal tract.
What this interaction means in plain words
Sulindac and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sulindac belongs to Musculoskeletal; Vortioxetine belongs to Central Nervous System.
Why it happens
Reduced platelet serotonin uptake impairs aggregation, adding to NSAID cyclooxygenase-mediated platelet inhibition and mucosal damage.
What to do
Monitor for bleeding and consider gastroprotection in patients at higher risk. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Sulindac with Vortioxetine?
MediHelp rates the interaction as moderate. Sulindac and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vortioxetine inhibits serotonin reuptake and can impair platelet function, so combined with an NSAID it increases the risk of bleeding, notably in the gastrointestinal tract.
How serious is the interaction between Sulindac and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and consider gastroprotection in patients at higher risk. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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