Drug interactions
Sumatriptan + Tedizolid
Severity: Moderate
Sumatriptan and Tedizolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sumatriptan is a 5-HT1B/1D agonist metabolized by MAO-A. Weak MAO inhibition by tedizolid could increase sumatriptan exposure and add serotonergic effects. The risk of serotonin syndrome is theoretical, with limited clinical data.
What this interaction means in plain words
Sumatriptan and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sumatriptan belongs to Central Nervous System; Tedizolid belongs to Anti Bacterial.
Why it happens
Weak MAO-A inhibition by tedizolid may reduce sumatriptan metabolism and add to serotonergic activity.
What to do
Monitor for serotonin toxicity and avoid repeated triptan dosing. Prefer a non-serotonergic antibiotic where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methamphetamine + Tedizolid Major
Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Frequently asked questions
Can I take Sumatriptan with Tedizolid?
MediHelp rates the interaction as moderate. Sumatriptan and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sumatriptan is a 5-HT1B/1D agonist metabolized by MAO-A. Weak MAO inhibition by tedizolid could increase sumatriptan exposure and add serotonergic effects. The risk of serotonin syndrome is theoretical, with limited clinical data.
How serious is the interaction between Sumatriptan and Tedizolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin toxicity and avoid repeated triptan dosing. Prefer a non-serotonergic antibiotic where possible.
What other medicines interact with Tedizolid?
MediHelp also lists interactions of Tedizolid with, for example, Bupropion, Cyproheptadine, Deferiprone. The full list is on the Tedizolid page.
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