Drug interactions
Sumatriptan + Trazodone
Severity: Moderate
Sumatriptan and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone has serotonergic activity, and combining it with a triptan carries a theoretical risk of serotonin syndrome. Documented cases are uncommon.
What this interaction means in plain words
Sumatriptan and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sumatriptan belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Additive serotonergic effects (serotonin reuptake inhibition by trazodone plus 5-HT1B/1D agonism).
What to do
Counsel patients to report agitation, tremor, sweating, diarrhea or fever. Monitor after dose changes and stop the triptan if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Frequently asked questions
Can I take Sumatriptan with Trazodone?
MediHelp rates the interaction as moderate. Sumatriptan and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone has serotonergic activity, and combining it with a triptan carries a theoretical risk of serotonin syndrome. Documented cases are uncommon.
How serious is the interaction between Sumatriptan and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report agitation, tremor, sweating, diarrhea or fever. Monitor after dose changes and stop the triptan if serotonin syndrome is suspected.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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