Drug interactions
Tacrolimus + Tazemetostat
Severity: Moderate
Tacrolimus and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak CYP3A4 inducer and may lower tacrolimus exposure. Tacrolimus is a CYP3A4 substrate with a narrow therapeutic index, so reduced levels risk inadequate immunosuppression.
What this interaction means in plain words
Tacrolimus and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tacrolimus belongs to Miscellaneous; Tazemetostat belongs to Miscellaneous.
Why it happens
Tazemetostat induces CYP3A4, increasing tacrolimus metabolism.
What to do
Monitor tacrolimus troughs when tazemetostat is started or stopped and adjust the dose to target.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Tacrolimus with Tazemetostat?
MediHelp rates the interaction as moderate. Tacrolimus and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is a weak CYP3A4 inducer and may lower tacrolimus exposure. Tacrolimus is a CYP3A4 substrate with a narrow therapeutic index, so reduced levels risk inadequate immunosuppression.
How serious is the interaction between Tacrolimus and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus troughs when tazemetostat is started or stopped and adjust the dose to target.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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