Drug interactions
Tacrolimus + Tecovirimat
Severity: Moderate
Tacrolimus and Tecovirimat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tecovirimat is a weak CYP3A4 inducer and may modestly reduce tacrolimus concentrations. Because of tacrolimus's narrow therapeutic range, even small decreases can matter.
What this interaction means in plain words
Tacrolimus and Tecovirimat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tacrolimus belongs to Miscellaneous; Tecovirimat belongs to Miscellaneous.
Why it happens
Weak induction of CYP3A4 by tecovirimat increases tacrolimus metabolism.
What to do
Monitor tacrolimus troughs during and after the tecovirimat course and adjust the dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Tecovirimat
- Bosentan + Tecovirimat Moderate
- Cyclosporin + Tecovirimat Moderate
- Darunavir + Tecovirimat Moderate
- Ethinyl estradiol-drospirenone + Tecovirimat Moderate
- Ethinyl estradiol-levonorgestrel + Tecovirimat Moderate
- Glimepiride-pioglitazone + Tecovirimat Moderate
Frequently asked questions
Can I take Tacrolimus with Tecovirimat?
MediHelp rates the interaction as moderate. Tacrolimus and Tecovirimat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tecovirimat is a weak CYP3A4 inducer and may modestly reduce tacrolimus concentrations. Because of tacrolimus's narrow therapeutic range, even small decreases can matter.
How serious is the interaction between Tacrolimus and Tecovirimat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus troughs during and after the tecovirimat course and adjust the dose as needed.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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