Drug interactions
Tacrolimus + Testosterone
Severity: Moderate
Tacrolimus and Testosterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgens have been reported to raise tacrolimus concentrations in isolated cases, possibly increasing the risk of nephrotoxicity and neurotoxicity. The evidence is limited.
What this interaction means in plain words
Tacrolimus and Testosterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tacrolimus belongs to Miscellaneous; Testosterone belongs to Endocrine.
Why it happens
Possible inhibition of CYP3A-mediated tacrolimus metabolism; the mechanism is not firmly established.
What to do
Monitor tacrolimus trough levels and renal function when starting or stopping testosterone, and adjust the tacrolimus dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Testosterone
- Testosterone + Warfarin Major
- Androstenedione + Testosterone Moderate
- Betamethasone + Testosterone Moderate
- Carbamazepine + Testosterone Moderate
- Corticotropin + Testosterone Moderate
- Cortisone + Testosterone Moderate
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Tacrolimus with Testosterone?
MediHelp rates the interaction as moderate. Tacrolimus and Testosterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgens have been reported to raise tacrolimus concentrations in isolated cases, possibly increasing the risk of nephrotoxicity and neurotoxicity. The evidence is limited.
How serious is the interaction between Tacrolimus and Testosterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough levels and renal function when starting or stopping testosterone, and adjust the tacrolimus dose accordingly.
What other medicines interact with Testosterone?
MediHelp also lists interactions of Testosterone with, for example, Warfarin, Androstenedione, Betamethasone. The full list is on the Testosterone page.
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