Drug interactions
Tacrolimus + Tolebrutinib
Severity: Moderate
Tacrolimus and Tolebrutinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolebrutinib may increase tacrolimus exposure through transporter inhibition. Elevated tacrolimus levels can cause nephrotoxicity, neurotoxicity and QT effects.
What this interaction means in plain words
Tacrolimus and Tolebrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tacrolimus belongs to Miscellaneous; Tolebrutinib belongs to Central Nervous System.
Why it happens
Inhibition of drug transporters such as P-glycoprotein may increase tacrolimus absorption and reduce elimination.
What to do
Monitor tacrolimus trough concentrations and renal function, and adjust the dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolebrutinib
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Tacrolimus with Tolebrutinib?
MediHelp rates the interaction as moderate. Tacrolimus and Tolebrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolebrutinib may increase tacrolimus exposure through transporter inhibition. Elevated tacrolimus levels can cause nephrotoxicity, neurotoxicity and QT effects.
How serious is the interaction between Tacrolimus and Tolebrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough concentrations and renal function, and adjust the dose as needed.
What other medicines interact with Tolebrutinib?
MediHelp also lists interactions of Tolebrutinib with, for example, Carbamazepine, Deferasirox, Efavirenz. The full list is on the Tolebrutinib page.
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