Drug interactions
Tacrolimus + Trastuzumab deruxtecan
Severity: Moderate
Tacrolimus and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab deruxtecan commonly causes neutropenia, and tacrolimus adds immunosuppression. Together they may increase the risk of serious infection.
What this interaction means in plain words
Tacrolimus and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tacrolimus belongs to Miscellaneous; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive immunosuppression and myelosuppression through different mechanisms.
What to do
Monitor neutrophil counts and for signs of infection, and treat fever promptly. Consider lowering tacrolimus targets if severe neutropenia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Tacrolimus with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Tacrolimus and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab deruxtecan commonly causes neutropenia, and tacrolimus adds immunosuppression. Together they may increase the risk of serious infection.
How serious is the interaction between Tacrolimus and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and for signs of infection, and treat fever promptly. Consider lowering tacrolimus targets if severe neutropenia occurs.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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