Drug interactions
Tacrolimus + Trofinetide
Severity: Moderate
Tacrolimus and Trofinetide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trofinetide is a weak CYP3A4 inhibitor and may modestly raise tacrolimus exposure. Tacrolimus has a narrow therapeutic index, so even small increases can lead to nephrotoxicity, neurotoxicity or hyperglycemia.
What this interaction means in plain words
Tacrolimus and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tacrolimus belongs to Miscellaneous; Trofinetide belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP3A4-mediated tacrolimus metabolism in the gut and liver.
What to do
Measure tacrolimus trough concentrations after starting or stopping trofinetide and adjust the dose accordingly. Monitor renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Trofinetide
Frequently asked questions
Can I take Tacrolimus with Trofinetide?
MediHelp rates the interaction as moderate. Tacrolimus and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trofinetide is a weak CYP3A4 inhibitor and may modestly raise tacrolimus exposure. Tacrolimus has a narrow therapeutic index, so even small increases can lead to nephrotoxicity, neurotoxicity or hyperglycemia.
How serious is the interaction between Tacrolimus and Trofinetide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure tacrolimus trough concentrations after starting or stopping trofinetide and adjust the dose accordingly. Monitor renal function.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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