Drug interactions
tacrolimus + voriconazole
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Marked ↑ tacrolimus levels → nephro/neurotoxicity.
Mechanism of action
CYP3A4 inhibition.
Clinical management
Reduce tacrolimus drastically; monitor troughs.
Drug reference
References
Frequently asked questions
Can I take tacrolimus with voriconazole?
The interaction is rated: Major. Marked ↑ tacrolimus levels → nephro/neurotoxicity.
How serious is the interaction between tacrolimus and voriconazole?
The interaction is rated: Major. Evidence level: High.
How is the interaction between tacrolimus and voriconazole managed?
Reduce tacrolimus drastically; monitor troughs.
Why do tacrolimus and voriconazole interact?
CYP3A4 inhibition.
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