Drug interactions
Tadalafil + Tucatinib
Severity: Moderate
Tadalafil and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is a moderate CYP3A inhibitor and may increase tadalafil concentrations. This may lead to hypotension, visual effects and priapism.
What this interaction means in plain words
Tadalafil and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tadalafil belongs to Genitourinary; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4, reducing tadalafil metabolism.
What to do
Use the lowest effective tadalafil dose with labeled dose limits and monitor blood pressure and adverse effects. Avoid in pulmonary hypertension where exposure rise could be harmful.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Tadalafil with Tucatinib?
MediHelp rates the interaction as moderate. Tadalafil and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib is a moderate CYP3A inhibitor and may increase tadalafil concentrations. This may lead to hypotension, visual effects and priapism.
How serious is the interaction between Tadalafil and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective tadalafil dose with labeled dose limits and monitor blood pressure and adverse effects. Avoid in pulmonary hypertension where exposure rise could be harmful.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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