Drug interactions
Talquetamab + Tizanidine
Severity: Moderate
Talquetamab and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Talquetamab causes cytokine release syndrome, which can transiently suppress CYP enzymes. Tizanidine exposure may increase, causing hypotension and sedation, especially during step-up dosing and for days afterward.
What this interaction means in plain words
Talquetamab and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Talquetamab belongs to Oncology; Tizanidine belongs to Musculoskeletal.
Why it happens
Cytokine-mediated suppression of CYP1A2 activity, decreasing tizanidine clearance.
What to do
Monitor blood pressure and sedation during talquetamab step-up dosing and any cytokine release syndrome. Consider temporarily reducing or holding tizanidine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Other interactions of Talquetamab
- Clozapine + Talquetamab Major
- Pimozide + Talquetamab Major
- Bendamustine + Talquetamab Moderate
- Carbamazepine + Talquetamab Moderate
- Clomipramine + Talquetamab Moderate
- Colchicine + Talquetamab Moderate
Frequently asked questions
Can I take Talquetamab with Tizanidine?
MediHelp rates the interaction as moderate. Talquetamab and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Talquetamab causes cytokine release syndrome, which can transiently suppress CYP enzymes. Tizanidine exposure may increase, causing hypotension and sedation, especially during step-up dosing and for days afterward.
How serious is the interaction between Talquetamab and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and sedation during talquetamab step-up dosing and any cytokine release syndrome. Consider temporarily reducing or holding tizanidine.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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